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KMID : 0363119920050010029
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Korean Journal of Pain
1992 Volume.5 No. 1 p.29 ~ p.36
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Effects of the Mixture of Morphine, Bupivacaine and Antidepressants by Continuous Epidural Infusion in Cancer and Non-cancer Pain
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신형철
김정순/김일호/송후빈/옥시영/황경호/박욱/김성열
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Abstract
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This study was objected to evaluate clinical progressions about both the degree of apin relief and the occurrence of morphine tolerance while the epidural analgesia with low dose of morphine, bupivacaine and antidepressant continued repeateldly
at
every
5 day intervals of the constant-rate infusion (0.5 ml/hr. 60ml capacity).
The subjects were divided to 56 cancer and 36 non-cancer patients who failed to respond to palliative treatments.
Before the relief of pain, the pain severity was moderate (10%) and severe (90%).
The dose escalation of morphine noted to 11 (20%) patients in cancer pain and to one (5%) case only in non-cancer.
During the epidural analgesia, the effect of pain relief was moderate (11%) and good (89%).
It suggest that the morphine tolerance may be reduced to some degree such as an initial minimum dose of epidural morphine with local anesthetic and antidepressant should be adjusted on an individual basis using the constant-rate infusor, even
though
rapid dose escalation occurrs in some patients who the diseases progress over a short period of time.
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KEYWORD
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